Stem Cell Line

CellActive Growth Factor 3%

RestructurActive Serum 10%

NanoFiller Lip Contour 3%

Stem Cell Integrity Mask
NanoFiller Lip Contour 3%
Staging: Stage III Antiaging
Age: Late 40s onwards
Properties: Stimulate Cellular Renewal
Body Part: Wrinkles
Usage: Home

 

The lip contour area is one of the most delicate on the face. Not being endowed with sebaceous glands, it is particularly dry and vulnerable to environmental aggressions such as excess sun, wind or air-conditioning. With the passage of time and the loss of filling material, expression wrinkles form in this area owing to repetitive mouth movements.

Stem Cell NanoFiller Lip Contour is the first filler based on vegetable stem cells and hyaluronic acid specifically designed for the treatment of the delicate lip contour area. This exclusive combination acts synergically and allows a dual effect:

  • Restructuring: the vegetable stem cells stimulate the production of collagen and elastin, prolonging cell life.
  • Filler: hyaluronic acid fills the most delicate areas, lending support to the cells created.

 

For more information, please contact us.

 

 

 

 The chronological ageing process of the skin happens in 4 stages.  In stage III, in addition to the characteristics of the earlier stages, there are also the following:

- Reduction in the quantity of cells which come to maturity to form the different skin structures (cellular renewal slows down)
- Loss of effectiveness in the metabolic processes which compensate for the skin normal deterioration
- Deterioration  in the outer layers of the epidermis and reduction of the quality of the tissues supporting the skin

As a consequence of theses changes there is a gradual disappearance of the skin’s elastic capacity together with a lack of firmness and the development of deep wrinkles.

PROPERTIES
Stem Cell professional treatment is a professional cosmetic anti-ageing method.  It consists of 5 treatment sessions in the salon + a home supplement.  The combined and sequential action of the different products stimulates the mechanisms of cellular renewal, promoting the regeneration of the different layers of the skin and combating deep wrinkles.

HOW TO USE
Start by cleansing the skin with hydra milk cleanser and then tone with hydratonic. When the skin is clean, apply optionally an ampoule of 10% of glycolic acid to increase cutaneous permeability and improve the effectiveness of the treatment.

Next prepare the massage lotion.  To do this mix three doses of the facial massage cream with a single dose of stem Cell serum restructurative and homogenize the mixture with a spatula.  Spread the mixture evenly over the face, neck and neckline, giving the special facial massage for 20 minutes.

Having finished the massage, apply stem cell crystal fiber mask to the face and leave it for 20 minutes to produce its firming and tensing action.

At the end of the 20 minutes, give a gentle relaxing massage on neck, face and neckline with one dose of the facial massage cream.

When the product has been absorbed, finish the professional treatment with an application of the moisturizing sun protection to protect the skin from harmful UV effects.

This professional treatment is supplemented with the daily application of stem cell growth factor.  Apply the cream twice a day on neck, face and neckline with a gentle circular massage until the product is completely absorbed.
 

 

 

What are human stem cells? What is the difference between differentiated cells and stem cells? Where can we find adult stem cells in the human body? Why are adult stem cells so important? Why are stem cells such a popular topic nowadays in the scientific community? What is the importance of adult stem cells in skin? Do plants also have stem cells? How are plant stem cells obtained? Why is vegetal biotechnology applied to plant stem cells so important? Why are plant stem cells important as active substance for the human skin? Which plant stem cell extract is Mesoestetic® Pharma Group using in their formulations? How is this plant stem cell extract produced to be used in skin care? Which effects do plant stem cells have on human stem cells and the aging process? Is there any scientific study about this effect? Is there any trial about the efficiency of a formulation with this active principle? What made the company decide to create a line of plant stem cells skincare products? What were the considerations that the company made in creating this range of products? How many products and what characteristics does Stem Cell line by Mesoestetic® have? What is the function of the growth factors used in the formulations? What is the function of the rest of the ingredients chosen to synergize the action of plan stem cells and growth factors? What is the application protocol of this line of products? Is Stem Cell line a shock or a continuous treatment? What kind of treatments is it associated to? Is it safe to use plant stem cells extract in cosmetics for humans? What target group of users would benefit from these products? How does Mesoestetic® guarantee the quality of these products?
 

What are human stem cells?

 

Human Stem Cells are defined as progenitor cells with the special ability of self-renew and also generate one or more differentiated cell types.

What is the difference between differentiated cells and stem cells?

 

Differentiated cells are the cells that perform the function in the different tissues to maintain the natural life span of the body. They cannot differentiate into another different type of cell. Human Stem Cells are cells that do not perform a direct function in the metabolism of the different tissues but they have the ability to evolve to differentiated cells. Therefore, Stem Cells have this special characteristic called pluripotency or totipotency depending on the kind of Stem Cells they are.

Where can we find adult stem cells in the human body?

 

The scientific literature has documented its existence in almost all tissues like bone marrow, skin, subcutaneous fat, heart and skeletal muscle, brain, retina, pancreas. They remain isolated and immature in their niche and they
mature when specific signals are received.

Why are adult stem cells so important?

 

The main reason why Stem Cells are important in living organisms is that in some adult tissues like bone marrow, muscle, brain, skin..., small defined populations of adult Stem Cells can migrate and replace cells that are lost in different organs as a result of normal wear and tear, injury or illness.
 
Thus, the main role of adult Stem Cells in a living organism is to maintain and repair the tissue in which they are keeping the life span of the body.

Why are stem cells such a popular topic nowadays in the scientific community?

 

From a therapeutic point of view there are still a lot of different diseases associated with the degeneration of tissues. So far, the way to cure and alleviate the symptoms was using transplants or drug therapies. The therapeutic potential of Stem Cells has opened the door to investigate treatments to enable regeneration of tissues affected, by stimulation and implementation of appropriate Stem Cells. Yet it takes years of research to reach acceptable results in many cases.

What is the importance of adult stem cells in skin?

 

Skin is the largest organ in the body and protects us from harmful particles and microorganisms as well from the Transepidermal Water Loss (TEWL). Because of this function there is a continuous degeneration of the outermost layers of the skin. So the skin needs to renew continuously the population of differentiated cells that we lose.
 
Adult Stem Cells on the skin provide these differentiated cells. During skin aging the process of differentiated cells replacement slows down because the population and the metabolism of Adult Skin Stem Cells decrease with the passing of time. These Adult Stem Cells are located in the basement membrane between dermis and epidermis and also near the hair bulge.

Do plants also have stem cells?

 

Yes, although cells from plants and animals are somewhat different, plants also have a kind of Stem Cells. In fact, plant cells are totipotent, and under the right conditions, from any plant cell the whole plant can be regenerated or the plant part of interest. That is a big difference to animal cells, because in animals only the real Stem Cells have this ability. Plant Stem Cells are Totipotent, which means they are somatic cells that have retained their ability to divide and differentiate into a mature plant if placed in appropriate media.

How are plant stem cells obtained?

 

When a plant is wounded, a callus tissue is formed (wound healing tissue). This is a mass of dedifferentiated cells, that means totipotential. In the callus tissue the normal differentiated cells go back into a dedifferentiated form and become Stem Cells (not possible in humans). Then they can be cultivated in the laboratory under controlled conditions providing the nutrients the cells need to grow. Then, just playing with the concentration of plant hormones it is possible to generate the part of the plant of interest.
 
This is the basis of vegetal biotechnology. 

Why is vegetal biotechnology applied to plant stem cells so important?

 

The techniques of vegetal biotechnology allow growing Plant Stem Cells in controlled, reproducible and sterile conditions. Then mass production of this callus tissue can be performed for different purposes.

Why are plant stem cells important as active substance for the human skin?

 

Recent scientific studies have shown the ability of vegetable Stem Cells to protect and regenerate our own skin Adult Stem Cells. Since Adult Stem Cells are the source of new differentiated skin cells it is very important to take care of them because their loss is much more dramatic than the regular loss of differentiated cells.

Which plant stem cell extract is Mesoestetic® Pharma Group using in their formulations?

 

Mesoestetic® Pharma Group R&D department decided to use a very special plant Stem Cell extract that have shown its ability in treating skin aging in different in vitro and in vivo assays. The plant Stem Cell extract used by mesoestetic® is produced from the fruit of Uttwiler Spätlauber, which is a special kind of apple tree. This apple tree has been cultivated because of these good storage properties. There are still some Uttwiler Spätlauber trees left in certain areas in Switzerland. So because of this good storage properties and conservation of the apple tree fruit some scientific studies were conducted to analyze if these plant Stem Cells could have any special property or characteristic for skin aging.

How is this plant stem cell extract produced to be used in skin care?

 

Callus tissue is generated from the fruit of Uttwiler Spätlauber. Then these undifferentiated cells are grown in bioreactors in controlled and sterile conditions. The mass of undifferentiated cells are lysated to obtain all components and biological structures they contain and are encapsulated in liposomes to improve the penetration through the skin layer to maximize the quantity of active substance that arrives to the specific target, which are Adult Skin Stem Cells.

Which effects do plant stem cells have on human stem cells and the aging process? Is there any scientific study about this effect?

 

Yes, we have in vitro assays conducted in scientific research laboratories from Switzerland that show the benefits that this extract has on our skin Stem Cells and on the cells involved in the maintenance of skin structure, like fibroblasts.
 
These assays have shown that this Plant Stem Cell Extract can protect human Stem Cells under harmful stimuli. It can also reverse the signs of senescence of human fibroblasts by studying expression of genes related to the proliferation process. It has also shown properties in delaying the senescence of hair bulges isolated from human scalp.
 
So, all this information together demonstrate the ability of this Plant Stem Cell extract to prevent, protect and reverse senescence in the important cells of skin as Adult Stem Cells and fibroblast are.

Is there any trial about the efficiency of a formulation with this active principle?

 

Yes. A clinical trial was performed in 20 patients applying a formulation with 2% of plant Stem Cell extract two times a day for 4 weeks. There was an improvement in the depth of wrinkles after the second week and this was increased after four weeks. This data was analyzed visually and by 3D analyzing software.

What made the company decide to create a line of plant stem cells skincare products?

 

Mesoestetic® is always aware about new trends in the cosmeceutical field, but only when these active substances have the support of scientific assays that confirm the activity. Biotechnology is going to be a very interesting field in cosmeceuticals. There is promising substance in this field with promising benefits for skin care. Plant Stem Cells showed their ability to protect our cells, and also demonstrated to be safe for human use. So R&D department decided to combine these excellent properties with other well known ingredients that can synergize their activity, like Hyaluronic acid, retinol, vitamins and peptides.

What were the considerations that the company made in creating this range of products?

 

The consideration of the company was to provide to our clients a new, innovative and effective alternative for the treatment of skin aging, taking advantage of the new ingredients in the biotechnology and science field.

How many products and what characteristics does Stem Cell line by Mesoestetic® have?

 

So far the family of Stem Cell is constituted by three products complementing each other. All of the products have Plant Stem Cell extract but they have in their formulation also special ingredients to synergize and increase this effect.
 
Stem CellActiveTM Growth Factor:
It is a cream that combines the action of Plant Stem Cells Extract (3%) with Growth Factors and additional ingredients like dexpanthenol, vitamins A&E, and peptides involved in the communication between cells.
 
Stem Cell NanoFillerTM Lip Contour:
Perioral filler based on plant Stem Cells (3%) and hyaluronic acid specifically designed to treat the delicate area around the mouth.
 
Stem Cell Serum RestructurActive:
Plant Stem Cells extract ultraconcentrated Serum (10%) with extra ingredients like growth factors and vitamins A&E. Provides an intensive shock treatment for the protection of our skin Stem Cells.
 
In all of these products mesoestetic® has decided to use higher concentrations of Plant Stem Cell extract than the one that was used in the clinical trial to be sure of this benefit effect.

What is the function of the growth factors used in the formulations?

 

These polypeptides have biological activity regulating the metabolic processes in the skin and hair growing by increasing cellular communication. Several in vivo studies carried out in human skin show that these polypeptides improve skin firmness and elasticity and increase the thickness and smoothness of the epidermis and dermis regeneration.

What is the function of the rest of the ingredients chosen to synergize the action of plan stem cells and growth factors?

 

Dexpanthenol: precursor of pantothenic acid (vitamin B5). It has a good moisturizing power and high capacity to set and store water; it is well absorbed through the skin.
 
Vitamin A: excellent antioxidant that moisturizes and protects the skin thanks to its ability to neutralize harmful free radicals.
 
Vitamin E: restructuring and anti-free radicals actions. It stimulates fibroblasts preventing tissue degeneration.
 
Synthetic peptides: mimic the action of endogenous peptides stimulating cell function and communication. Favors the stimulation of fibroblasts and collagen synthesis.
 
Hyaluronic Acid: an excellent physiological lubricant. Its high water holding capacity carries out a long lasting moisturizing effect. It is also involved in the repairing processes of the skin, through the stimulation of certain receptors.
 
Lipochroman-6: last generation anti-radical that protects the cells against Oxygen Free Radicals and Nitrogen Free Radicals, inhibiting interferences in the cellular functions.

What is the application protocol of this line of products?

 

Stem Cell line has been designed as an integral treatment. The different products can be used separately but their action will strengthen if combined all together.
 
StemCell serum Restructuractive is a shock effect product to be used in early treatment on alternate nights. At night the skin rests and recovers from its daily efforts
without being exposed to environmental aggressions. It is the ideal way to start to revive the cells.
 
During this first step, it should ideally be used together with the maintenance products, StemCellactive Growth Factor and Stem Cell Nanofiller.
 
StemCellactive Growth Factor is designed to treat face and neck during the day providing a continuous protection and regeneration of our skin stem cells.
 
Stem Cell Nanofiller is designed to treat the delicate lip contour area which needs special hydration.

Is Stem Cell line a shock or a continuous treatment?

 

Since Stem Cell line has been designed to stop the cell renewal slowing down, the first step is actually a 5 weeks shock treatment combining StemCell serum Restructuractive and with the 2 maintenance products: StemCellactive Growth Factor and Stem Cell Nanofiller.
 
After the shock treatment, it is very important to keep on using the maintenance products in order to continuously improve the natural capacity of the skin for self-repair.
 
The shock treatment can be repeated every three months.

What kind of treatments is it associated to?

 

Stem Cell line is designed as a powerful cosmeceutical to fight against skin aging in an integral way. One of the concepts that has been taken into account while developing the line was to create a treatment that could perform its effect taking advantage of the different actions of the ingredients of the formula.
 
Therefore, Stem Cell line is a perfect complement for the recovery of the skin after some types of slightly aggressive treatments such as peelings, pulsed light or microdermoabrasion.
 
Stem Cell line has also been designed to be combined with the rest of mesoestetic® range of products such as:
  • post-peel crystal fiber mask: a latest generation face mask, specifically created to facilitate the process of cell renewal.
  • power patch: microelectronic cosmetic patches for specific care of the eye contour.

Is it safe to use plant stem cells extract in cosmetics for humans?

 

This active substance has been shown to be totally safe during its development and its testing on clinical trials.

What target group of users would benefit from these products?

 

These products are suitable for any group of people that suffer from skin aging. Beyond 30 years old, human beings start to develop the process of skin aging in a dramatic way. The processes involved in the maintenance of the thickness of dermis, or the good characteristics of skin slow down, so there is an acceleration in the deterioration of the different structures of skin. These kinds of products help to balance again between the normal deterioration that occurs with the passing of time and the self-renewal that the body maintains in the skin. So it is specifically designed for people from 40 years old.

How does Mesoestetic® guarantee the quality of these products?

 

Like all mesoestetic® products, Stem Cell line is manufactured under the highest quality standards. Since Mesoestetic® Pharma Group is a pharmaceutical laboratory, GMP (Good Manufacture Procedures, a pharmaceutical standard quality) are applied to all the steps of the production, from the election of the suppliers, who have to fulfill with high requirements to the deliver of the product to the customer.
 
All the steps of the manufacturing process are controlled. Physical and chemical analysis of the finished product as well as strict microbiological controls are carried out in order to guarantee the highest quality to the professionals who trust us.
 
Like in the rest of its formulas, mesoestetic® also guarantees the highest concentrations of active principals.

our authorised doctors & clinics for Stem Cell Line

Dr Woffles T.L. Wu
Woffles Wu Aesthetic Surgery & Laser Centre
1 Orchard Boulevard 
#09-02 Camden Medical Centre
Singapore 249615 

Tel: +65 6733 9771
www.woffleswu.com
Dr Patrina Wong Lai Lin
LinC Aesthetic Clinic Pte Ltd
541 Orchard Road #21-01/02 Liat Towers Singapore 238881
Tel: +65 6732 0208
www.linc.com.sg
Dr Y M Wong
Clinic Suisse
290 Orchard Rd Paragon Medical Centre #08-01 Singapore 238859
Tel: +65 6235 4040
www.clinicsuisse.com
Dr Joseph See
SEE Medical Aesthetics
1 Scotts Road
#27-00 Shaw Centre
Singapore 228208

Tel: +65 6738 8842
www.seeaesthetics.co
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